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Full details can be found in our publication: Dagostino R, Gottlieb A. Tissue-specific atlas of trans-models for gene regulation elucidates complex regulation patterns. BMC genomics. 2024 Apr 17;25(1):377.
A Tutorial provides examples of use cases for the networks available on this site
This website provides two sets of networks:
- Genes that are co-regulated across multiple tissues based on our published method. These networks are correlation-based and non-directional.
- Regulatory networks, where a variation in a TF is associated with variation in a gene expression, but the expression levels of the TF are themselves associated with a higher-level TF. These networks show cascades of regulation, where TFs could regulate other TFs, which in turn regulate gene expression. To allow convenient browsing, we provide networks that show only the genes+TFs that are themselves regulated and the full networks, that show all TFs, including ones that were not directly regulate in our models.
The networks were constructed using Cytoscape and enables the exploration of these networks using different visual styles and layouts. Users can also use the files available to download to construct their own networks.
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