About TFReglome

Deciphering gene regulatory relations is essential for understanding the underlying mecha-nisms of healthy and disease states. Within the regulatory relations formed by transcription factors (TFs) and their target genes, we studied trans effects of TFs on the expression of their transcribed genes, exposing a high order of regulation.

We provide a comprehensive map of tissue-specific associations between expression and binding variations within TFs and the expression of their associated genes.

Using machine learning models for genetically regulated expression, our approach tested two possible mechanisms by which variations in TFs can affect gene expression, including variability in the expression of the TF, and genetic variants within the TF gene that may affect binding affinity of the TF to the TF binding site.

Our tissue-specific map provides tissue-specific Complex genetic regulation associations that can be further tested for association with tissue-specific phenotypes.

Read our Help page to see a tutorial about using the networks on this website and possible use cases.
How to cite:

Lu, Hengwei, Yi-Ching Tang, and Assaf Gottlieb. "Tissue-Specific Variations in Transcription Factors Elucidate Complex Immune System Regulation." Genes 13, no. 5 (2022): 929.

Co-regulation across tissues

Explore Co-regulation networks

* If you require accommodation to access the information contained in this interactive map, please contact us for assistance. Data contained in the map can also be obtained from the Download page.

Regulation cascade maps

Sub-Networks of the full tissue-specific networks.

Displayed are regulatory cascades, including only TFs that are themselves trans-regulated, enabling easier viewing

Explore the cascades of regulatory networks

* If you require accommodation to access the information contained in this interactive map, please contact us for assistance. Data contained in the map can also be obtained from the Download page.

Full regulation maps

Full networks

Explore the full regulatory networks

* If you require accommodation to access the information contained in this interactive map, please contact us for assistance. Data contained in the map can also be obtained from the Download page.